Quartz Crystal Microbalance QCMagic ( QCM)


The Quartz Crystal Microbalance QCMagic (QCM) set-up has been designed to directly drive piezoelectric transducers. It consists of single/multiple measuring units, driven by a USB base unit, suitable for:

  • biosensor development

  • affinity reaction studies

  • association/dissociation and kinetic constants determination

  • monoclonal antibodies characterization

  • binding site mapping

  • DNA hybridization

  • analysis of electrochemical deposition, polymers coated on electrodes, corrosion, adsorption and electrochemical reaction mechanisms

  • multi-probing detection

QCMagic is a high precision measuring instrument featuring excellent performance in the recovery of the oscillation frequency of a working quartz crystal.The system is interfaced to the driving PC by means of the USB port. One single Base Unit can drive up to 4 oscillator modules, thus allowing to operate with up to 4 independent quartz crystals (or with two pairs of working/reference crystals). QCMagic can be equipped with low-volume static or flow-through reaction chambers, which house the oscillating crystal; fitting the transducer into the different type of cells is rapid and convenient. QCMagic makes use of a precision internal reference crystal, used as a timebase comparator. Depending on the frequency of this internal timebase, each Unit can be tuned to work with a specific working crystal, choosen between 1 and 10 MHz. The Oscillator Modules are connected to the Base Unit by means of a RJ45 cable carrying both power supply and signals.

 

[click on the images to enlarge]

 

 

QCMagic is interfaced with a personal computer by USB port for data acquisition and storage. The system is driven by an extremely user-friendly software running under MS-WindowsTM. It consist of a lower level kernel which implements the necessary data transfer between the computer and the unit(s), and of a high level set of routines which drive the user through an easy to perform data acquisition and analysis. In addition to the data acquisition service routine, an useful data display has been implemented by which the user can easily retrieve the acquired signal levels. Oscillating frequency versus time measurements can be performed following the data acqusition in real time on the computer screen, by means of strip chart plotting.

Max resolution (gate dependent) ±0.05 Hz 

Gate interval 0.01 to 10 s

Frequency stability 100 ppm/°C

Counter logic 32 bit

Air oscillator TTL compatible

Liquid oscillator TTL compatible

Interface USB port

Instrument output delta f (proportional to electrode mass)

Biochemical output analyte concentration

Transducer quartz crystal AT-cut, 9.5 MHz (standard)1 to 10 MHz (optional)

Units 1 to 4

Crystal port standard 125 mm

Warm-up interval 30-40 min (only after first power-up to meet above stability specifications)

Software Real time frequency data via dedicated software (windows application running under Win 9x, NT, 2000, XP, Vista)

Physical dimensions(base Unit) 165 x 35 x 65 mm (L x H x W)

Power supply external +12 Vdc

Operating temperature 0° to 55°C

 

Optionally we can provide an additional software tool "QCMath" allowing a mathematical analysis on acquired data or on any .xls (Microsoft Excel) data file.
QCMath allows these fittings:

  • Linear FittingOne Site Binding

  • Sigmoidal Dose Response

  • Sigmoidal Dose Response variable slope

  • One Site Competition

  • One Phase Exponential Decay

  • Two Phase Exponential Decay

  • One Phase Exponential Association

  • Polynomial 1° order

  • Polynomial 2° order

  • Polynomial 3° order

  • Polynomial 4° order

Download QCMagic Manual

 

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