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Our activities:

Design and realization of precision Scanning Probe Microscopy solutions, including controlling electronics with dedicated and specialized software according to the customers needs; design and realization of top-quality High Voltage Amplifiers; design and realization of an fast data acquisition electronic systems; design and development of software tools for images digital elaboration; design and realization of hardware "custom" systems, among which High and Low Voltage power sources; design and realization of PC-based data acquisition systems; design and development of software tools for adapting commercial hardware systems to specific requirements of the customers. Feasibility studies. Training activities (high level courses in computer science)

 

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Seminars and Workshops

  • Attendance to the seminar "Non-conventional microscopies", Istituto di Biofisica, CNR  Pisa,  with an oral presentation: "Industrial development of an  electronics system for  SPM: a real example of technology transfer".

  • Attendance to the seminar "Scanning probe microscopy: from the physical principle to  the pratical implementation", Facoltà di Ingegneria, Università di Firenze, with an oral presentation.

  • Attendance to "TED 2002" - Innovation technologies in Training Fair, Genova, Fiera del Mare, with a stand presenting two applications:

  • Mr.Tip, Atomic Force Microscope for training applications

  • Virtual Cattedra, software suite for PC-based tests

  • press bulletin

  • Attendance to the specialization course "Innovative Microscopies for Biotechnology", Facoltà di Medicina e Chirurgia, Università di Firenze, with a theoretical and practical lesson on SPM. 2002 and 2003

  • Attendance to a coordination meeting in the framework "Network of excellence on Proteomics: a dynamical approach" Firenze, November 4-5, 2002 Università di Firenze, Dipartimento di Energetica

  • Slides of the meeting

XC Congresso Nazionali Società Italiana di Fisica - Brescia 20-25 Settembre 2004
M.Vassalli, M.Basso, M.Sartore, B.Tiribilli, F.Quercioli, F.Azzurri 
AFM Control system for biological application

The 6th Workshop on Biosensors and BioAnalytical-Techniques in Environmental and Clinical Analysis October 8-12, 2004,
ENEA,S. Maria di Galeria, Rome, Italy
Poster section DNA08:
A NOVEL PIEZOELECTRIC BIOSENSOR FORMAT FOR THE DETECTION OF CLINICALLY RELEVANT TP53 GENE MUTATION
M.Minunni 1, M.Adami 2, D.Dell’Atti 1, S.Tombelli 1, M.M.Spiriti 1, M.Mascini 1
1. Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze (Italy) - minunni@unifi.it- 2. ElbaTech s.r.l., Via Roma 1, 57030 Marciana (LI) (Italy)
Abstract Link 
Download the Poster (849 KB)

Micos Italia Gmbh
"Tecnologia piezo per 'NANO posizionamento'"

Research program
Interaction between cytoplasm proteins and membranes: a study of lipoxygenases as a model in vitro and in vivo.

University Co-ordinator Università Cattolica del Sacro Cuore - Fisica - MILANO Research Unit Leader: Giuseppe ARCOVITO
Description: We aim to utilize the following different lipoxygenases: LOX-1, mini-LOX, apo-mini-LOX, this last also reconstituted with metals different than iron. These lipoxygenases will be used to: i) determine their aggregation kinetics; ii) characterize formed clusters; iii) investigate the modalities of the interaction between the monomeric or aggregated for of lipoxygenase and synthetic or natural membranes. For this last point, particular attention will be given to the interaction with raft or non-raft membrane microdomains.

http://www.ricercaitaliana.it/prin/unita_op-2005052299_002.htm

Clinica Chimica Acta 2007
Development of combined DNA-based piezoelectric biosensors for the simultaneous detection and genotyping of high risk Human Papilloma Virus strains
Daniela Dell’Atti a, Michele Zavaglia a, Sara Tombelli a, Gloria Bertacca b, Andrea O. Cavazzana b, Generoso Bevilacqua b, Maria Minunni a,⁎, Marco Mascini a a Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino, Italy b Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Via Roma 47, 5600 Pisa, Italy

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The FASEB Journal article fj.07-8189com. Published online July 2, 2007
Globular structure of human ovulatory cervical mucus
Roberto Brunelli,*,1 Massimiliano Papi,†,1 Giuseppe Arcovito,† Adriano Bompiani,§ Massimo Castagnola,‡,§, Tiziana Parasassi,¶ Beatrice Sampaolese, Federica Vincenzoni,§ and Marco De Spirito†,2 *Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Universita` di Roma La Sapienza, Italy; †Istituto di Fisica; §Istituto Scientifico Internazionale “Paolo VI,” Rome, Italy; and ‡Istituto di Biochimica e Biochimica clinica, Facolta` di Medicina e Chirurgia, Universita` Cattolica del Sacro Cuore, Rome, Italy; and Istituto per la Chimica del Riconsimento Molecolare and ¶Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy

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Biophysical Journal Volume 90 June 2006 4239–4247

Low Density Lipoprotein Aged in Plasma Forms Clusters ResemblingSubendothelial Droplets: Aggregation via Surface Sites Marco De Spirito,* Roberto Brunelli,y Giampiero Mei,z Francesca R. Bertani,§ Gabriele Ciasca,* Giulia Greco,§ Massimiliano Papi,* Giuseppe Arcovito,* Fulvio Ursini,** and Tiziana Parasassi§ *Istituto di Fisica, Facolta` di Medicina e Chirurgia, Universita` Cattolica del Sacro Cuore, Rome, Italy; yDipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Universita` di Roma ‘‘La Sapienza’’, Rome, Italy; zDipartimento di Medicina Sperimentale e Scienze Biochimiche, Universita` di Roma ‘‘Tor Vergata’’, Rome, Italy; §Istituto di Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche, Rome, Italy; and **Dipartimento di Chimica Biologica, Universita` di Padova, Padua, Italy

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APPLIED PHYSICS LETTERS 88, 194102 2006

Fluid viscosity determination by means of uncalibrated atomic force microscopy cantilevers Massimiliano Papi, Giuseppe Arcovito, and Marco De Spiritoa  Istituto di Fisica, Universitá Cattolica S. Cuore, Largo Francesco Vito, 1 I-00168, Roma, Italy Massimo Vassalli and Bruno Tiribilli Istituto Sistemi Complessi, CNR, Largo Enrico Fermi, 6 I-50125, Firenze, Italy

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16-21 July 2007, Portoconte, 6th Centralized Seminar on Biocatalysis
Proteome: Technologies and Applications Link

 

02 October 2009 B-Day - Area Science Park Trieste

 

07 February 2011 AISEM XVI Conf. Nazionale Sensori e Microsistemi

M.Sartore: Elbatech QCMagic, multichannel nanogravimetric system

 

S. Scarano, M.M. Spiriti, G.Tigli, P. Bogani, M. Buiatti, M. Mascini and M. Minunni, Affinity Sensing for transgenes detection in anti-doping control, Analytical Chemsitry, 2009, 81 (23), 9571-9577; (IF 2010 5.712, IF 2009: 5.712; this work has been mentioned in the News of Bioanalysis, number of January 2010 and reviewed on Chemistry World by RCS, Februar 2010,

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SPECIAL ISSUE: NANOSTRUCTURED MATERIALS 2010
J Nanopart Res DOI 10.1007/s11051-011-0327-x
Controlled self assembly of collagen nanoparticle
Massimiliano Papi • Valentina Palmieri • Giuseppe Maulucci •
Giuseppe Arcovito • Emanuela Greco • Gianluca Quintiliani •
Maurizio Fraziano • Marco De Spirito

Mechanical properties of zona pellucida hardening
Eur Biophys J (2010) 39:987–992
DOI 10.1007/s00249-009-0468-3
Massimiliano Papi Æ Roberto Brunelli Æ Lakamy Sylla Æ Tiziana Parasassi Æ
Maurizio Monaci Æ Giuseppe Maulucci Æ Mauro Missori Æ Giuseppe Arcovito Æ
Fulvio Ursini Æ Marco De Spirito

APPLIED PHYSICS LETTERS 94, 153902 2009
Evidence of elastic to plastic transition in the zona pellucida of oocytes
using atomic force spectroscopy
Massimiliano Papi,1 Lakamy Sylla,2 Tiziana Parasassi,3 Roberto Brunelli,4
Maurizio Monaci,2 Giuseppe Maulucci,1 Mauro Missori,1 Giuseppe Arcovito,1 Fulvio Ursini,5
and Marco De Spirito1,

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